Bleeding is one of the most serious and most frequent complications encountered in patients who suffer from cirrhosis of the liver. Therefore, the maintenance of good capillary resistance is of life-saving importance. The efficacy of OPCs in improving capillary resistance in patients suffering from cirrhosis of the liver was tested (double-blindly) in 1983. The researchers reported that with a dosage of 300 mg of OPC per day, they induced a significant improvement of capillary fragility.
(Effect de l’Endotélon sur l’indice de fragilité capillaire dans une population spécifique: les sujets cirrhotiques. F.X. Lesbre et J.D. Tigaud. Gaz. Med. de France - 90, no 24 du 24-VI-1983.)